Table 4.
Genotype distribution of the three polymorphisms involved in regulation of arteries tension in infants without and with NEC and without/with NEC surgery-requiring
| Gene symbol db SNP |
Genotypes/allele | Group without NEC N (%) |
Group with NEC N (%) |
p | OR 95% CI p |
Group with NEC without surgery N (%) |
Group with NEC with surgery N (%) |
p | OR 95% CI p |
|---|---|---|---|---|---|---|---|---|---|
| eNOS 894G>T (rs1799983) |
GG | 45 (57.69) | 9 (40.91) | – | References | 50 (53.76) | 4 (57.14) | – | References |
| GT | 31 (39.74) | 5 (22.73) | 0.964 | 0.807 (0.193–3.00) | 35 (37.63) | 1 (14.29) | 0.662 | 0.357 (0.007–3.850) | |
| TT | 2 (2.56) | 8 (36.36) | 0.0004 | 20 (3.71–208.7) | 8 (8.60) | 2 (28.57) | 0.467 | 3.125 (0.239–25.81) | |
| G | 121 (77.56) | 23 (52.27) | – | References | 135 (72.58) | 9 (64.29) | – | References | |
| T | 35 (22.44) | 21 (47.73) | 0.003 | 3.157 (1.466–6.726) | 51 (27.42) | 5 (35.71) | 0.696 | 1.471 (0.368–5.156) | |
| eNOS −786T>C (rs2070744) |
TT | 32 (41.03) | 6 (27.27) | – | References | 38 (40.86) | 0 (0.00) | – | References |
| TC | 40 (51.28) | 11 (50.00) | 0.685 | 1.467 (0.437–5.362) | 47 (50.54) | 4 (57.14) | – | – | |
| CC | 6 (7.69) | 5 (22.73) | 0.105 | 4.444 (0.773–24.27) | 8 (8.60) | 3 (42.86) | – | – | |
| T | 104 (66.67) | 23 (52.27) | – | References | 123 (66.13) | 4 (40.00) | – | References | |
| C | 52 (33.33) | 21 (47.73) | 0.118 | 1.826 (0.871–3.799) | 63 (33.87) | 10 (60.00) | 0.013 | 4.881 (1.330–21.99) | |
| END-1 5665G>T (rs5370) |
GG | 52 (66.67) | 14 (63.64) | – | References | 63 (67.74) | 3 (42.86) | – | References |
| GT | 24 (30.77) | 7 (31.82) | 1.000 | 1.083 (0.326–3.329) | 28 (30.11) | 3 (42.86) | 0.577 | 2.250 (0.281–17.70) | |
| TT | 2 (2.56) | 1 (4.55) | 1.000 | 1.857 (0.029–37.76) | 2 (2.15) | 1 (14.29) | 0.333 | 10.5 (0.134–243.2) | |
| G | 128 (82.05) | 35 (79.55) | – | References | 154 (82.80) | 9 (64.29) | – | References | |
| T | 28 (17.95) | 9 (20.45) | 0.854 | 1.176 (0.445–2.863) | 32 (17.20) | 5 (35.71) | 0.184 | 2.674 (0.655–9.549) |
Results are expressed as absolute number of patients (percentage). The odds ratio (OR) and 95% confidence intervals (95% CI)
END-1 endothelin-1, eNOS endothelial nitric oxide synthase, NEC necrotizing enterocolitis