Activity of a AMP deaminase (AMPD), b ecto5′-nucleotidase (e5NT), c adenosine deaminase (ADA), d purine nucleoside phosphorylase (PNP) in kidney divided into cortex and medulla and then frozen. C control mice that drunk water, Caff mice drunk caffeine coffee, LDC mice treated low-dose decaffeinated coffee, HDC mice treated high-dose decaffeinated coffee. Values are mean ± SD n = 6, a *p < 0.05 versus all cortex and all medulla; **p < 0.05 versus all cortex and C, Caff, LDC medulla b *p < 0.05 versus C, HDC cortex and all medulla; **p < 0.05 versus C, HDC cortex and all medulla; ***p < 0.05 versus all cortex and C medulla; #
p < 0.05 versus all cortex and all medulla; and p < 0.05 versus Caff, LDC cortex and all medulla; $
p < 0.05 versus HDC medulla; ##
p < 0.05 versus C cortex c *p < 0.05 versus Caff, LDC cortex and C, HDC medulla; **p < 0.05 versus HDC cortex and all medulla; ***p < 0.05 versus all medulla; #
p < 0.05 versus LDC, HDC medulla; and p < 0.05 versus C, HDC medulla d *p < 0.05 versus C, LDC, HDC medulla; **p < 0.05 versus C, HDC medulla; ***p < 0.05 versus HDC medulla; #
p < 0.05 versus C cortex; and p < 0.05 versus all medulla; $
p < 0.05 versus C cortex