Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 11;40(1):49–64. doi: 10.1007/s00281-017-0663-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 2 — Overlap of C3G and MPGN. A cause of uncontrolled complement activation should be suspected in cases of C3 glomerulopathy (bold circle). Specific forms of C3G include C3GN, DDD, and CFHR5 nephropathy. Light microscopy identifies a diverse pattern of glomerular injury that includes MPGN. Uncontrolled complement activation has also been identified in cases of immune-complex MPGN (shaded)—these are cases of MPGN that do not fulfill current criteria for C3G. Causes of uncontrolled complement activation should be considered in an overlapping group of C3G and MPGN