. 2018 Jan 11;40(1):49–64. doi: 10.1007/s00281-017-0663-8

Table 3.

Abnormal FHR proteins described in C3G

Abnormal FHR protein	Phenotype	Effect	Reference
FHR2₁₂FHR5_1–9	DDD	Stabilizes C3bBb	[99, 100]
FHR5₁₂FHR5_1–9	CFHR5 nephropathy	De-regulates FH	[97, 98]
FHR5₁₂FHR2_1–4	C3GN	Not known	[101]
FHR1₁₂₃₄FHR1_1–5	Low C3	De-regulates FH	[102]
FHR3₁₂FHR1_1–5	C3GN	De-regulates FH	[97, 103]
FHR1₁₂₃FHR5_1–9	DDD/C3GN overlap	De-regulates FH	[104]
FHR5₁₂FHR2_1–4	C3GN	De-regulates FH	[105]

Abnormal FHR protein—the subscript indicates the SCR of each FHR protein that form the abnormal FHR protein

FHR factor H-related, DDD dense deposit disease, C3GN C3 glomerulonephritis, C3bBb C3 convertase of the alternative pathway, FH factor H