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. 2018 Feb 1;8:2073. doi: 10.1038/s41598-018-20431-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-539 was significantly down-regulated in breast cancer tissues and cell lines. (A) Relative expression levels of miR-539 in 38 pairs of breast cancer tissues and matched normal breast tissues were analysed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). (B) Relative expression of miR-539 in two breast cancer cell lines (MDA-MB-231 and MCF7) and a human normal mammary epithelial cell line (MCF-10A). miRNA: microRNA. *P < 0.05.