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. 2018 Feb 1;8:2073. doi: 10.1038/s41598-018-20431-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enforced expression of miR-539 suppresses tumor growth in nude mice. (A) Representative images of the mice carrying tumors are shown after 28 days of inoculation with MDA-MB-231 cells expressing miR-539 or negative control. (B) Measurement of tumor volumes at the indicated time points. Measurement of the final volume (C) and weight (D) of xenograft model at day 28. *P < 0.05.