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. 2018 Feb 1;8:2073. doi: 10.1038/s41598-018-20431-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ectopic over-expression of EGFR partially reversed miR-539-inhibited proliferation and migration of breast cancer cells. (A) The relative expression levels of EGFR in MDA-MB-231 and MCF7 cells were analyzed by RT-qPCR and Western blot. (B) The proliferation of MDA-MB-231 and MCF7 cells was measured by the MTT assay after miR-539 mimics or miR-539 mimics and pcDNA3.1-EGFR plasmid or miR-539 mimics and pcDNA3.1-empty vector infection. (C) A wound healing assay was measured and compared between MDA-MB-231 and MCF7 cells transfected with miR-539 mimics and pcDNA3.1-EGFR plasmid and cells treated with miR-539 mimics and pcDNA3.1-empty vector (Magnification x 200). *P < 0.05.