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. 2018 Feb 1;8:2035. doi: 10.1038/s41598-018-20400-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum VIP levels in EA patients according to different genotypes. Serum VIP levels according to the genotype of the: (a) rs688136; (b) rs12201140; (c) rs35643203. (d) Interaction Score for different genotype combinations of VIP gene polymorphisms associated with VIP serum levels. In all panels data from the meta-analysis (n = 222) are presented as the interquartile range (p75 upper edge of the box, p25 bottom edge, and p50 midline), p90 and p10 (lines below and above the box) of the serum VIP levels. Statistical significance for a p-value < 0.05 was established by means of a multivariate analysis adjusted by age of onset and TNFα blockers and nested by patient and visit. Dots represent outliers. ns: non-significant.