Table 3.
Association of genotype combinations of the Interaction Score with the Intensity of Treatment in patients with early arthritis. Multivariable analysis.
| β coeff ± SE | p | |
|---|---|---|
| Interaction Score | ||
| CT or TT and no other minor alleles | Ref. | |
| CT or TT and other minor alleles | −0.14 ± 0.09 | 0.131 |
| CC and no other minor alleles | −0.62 ± 0.24 | 0.009 |
| CC and other minor alleles | −0.04 ± 0.19 | 0.849 |
| Gender | ||
| Male | Ref. | |
| Female | 0.15 ± 0.11 | 0.174 |
| OnsetAge | ||
| <45 | Ref. | |
| 45–65 | −0.01 ± 0.11 | 0.958 |
| >65 | −0.11 ± 0.12 | 0.363 |
| Diagnosis | ||
| RA | Ref. | |
| UA | −0.85 ± 0.11 | 0.000 |
| ACPA | ||
| Negative | Ref. | |
| Positive | 0.12 ± 0.10 | 0.226 |
| Physician | ||
| 0 | Ref. | |
| 1 | 0.09 ± 0.18 | 0.660 |
| 2 | 0.69 ± 0.14 | 0.000 |
| 3 | −0.41 ± 0.24 | 0.119 |
| 4 | 0.06 ± 0.14 | 0.621 |
| 5 | 0.31 ± 0.16 | 0.042 |
| 6 | 0.32 ± 0.13 | 0.007 |
Association analysis performed with data corresponding to the meta-analysis (n = 222). Signification was established by means of generalized estimating equations. Multivariable model fitted by a backward-stepwise selection. Ref.: reference value; β coeff: beta coefficient; SE: standard error.