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. 2018 Feb 1;8:2118. doi: 10.1038/s41598-018-20266-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional Analyses RNA-Seq data. (A) Overlap of the significant DE expressed liver transcripts (FDR < 0.4) from 5.8 nM DEHP and 0.65 nM EE2 exposed adult male zebrafish relative to control fish as determined by DESeq. 2. (B–D) Gene Ontology Biological Process analyses: Scatterplots shows the cluster representatives (i.e. terms remaining after the redundancy reduction) in a two dimensional space derived by applying multidimensional scaling to a matrix of the GO terms’ semantic similarities. Bubble color indicates the p-value (legend in upper right-hand corner); size indicates the frequency of the GO term in the underlying GOA database (bubbles of more general terms are larger). GO BP analysis of DE genes in (B) DEHP and (C) EE2 exposed livers. (D) GO BP analysis of DE genes unique to DEHP (not DE in EE2 exposed).