Table 1.
GOrilla functional enrichment analysis.
| GO Term | q-value |
|---|---|
| DEHP-Total | |
| chitin metabolic process | 4.46E-05 |
| chitin catabolic process | 8.91E-05 |
| amino sugar catabolic process | 1.16E-04 |
| glucosamine-containing compound metabolic process | 1.39E-04 |
| glucosamine-containing compound catabolic process | 1.74E-04 |
| aminoglycan catabolic process | 2.31E-04 |
| amino sugar metabolic process | 8.38E-04 |
| aminoglycan metabolic process | 3.38E-03 |
| carbohydrate derivative catabolic process | 8.12E-03 |
| sulfur compound transport | 2.82E-02 |
| sulfate transport | 3.10E-02 |
| anion transport | 3.44E-02 |
| ion transport | 3.63E-02 |
| inorganic anion transport | 5.55E-02 |
| transmembrane transport | 5.71E-02 |
| response to vitamin B3 | 1.28E-01 |
| organonitrogen compound catabolic process | 1.69E-01 |
| monovalent inorganic cation homeostasis | 2.07E-01 |
| EE2-Total | |
| organic acid metabolic process | 9.31E-03 |
| monocarboxylic acid metabolic process | 1.12E-02 |
| carboxylic acid metabolic process | 1.14E-02 |
| oxoacid metabolic process | 1.16E-02 |
| fatty acid metabolic process | 1.53E-02 |
| long-chain fatty acid metabolic process | 4.58E-02 |
| lipid metabolic process | 5.10E-02 |
| single-organism metabolic process | 5.51E-02 |
| small molecule metabolic process | 1.12E-01 |
| unsaturated fatty acid metabolic process | 1.25E-01 |
| carboxylic acid transmembrane transport | 1.30E-01 |
| response to lipid | 1.35E-01 |
| long-chain fatty acid biosynthetic process | 1.38E-01 |
| organic acid transmembrane transport | 1.39E-01 |
| response to biotic stimulus | 1.44E-01 |
| response to external biotic stimulus | 1.56E-01 |
| epoxygenase P450 pathway | 1.87E-01 |
| monounsaturated fatty acid metabolic process | 2.14E-01 |
| response to external stimulus | 2.23E-01 |
| monounsaturated fatty acid biosynthetic process | 2.26E-01 |
| DEHP-Unique | |
| negative regulation of cellular biosynthetic process | 1.35E-01 |
| negative regulation of gene expression | 1.44E-01 |
| negative regulation of biosynthetic process | 1.62E-01 |
| regulation of translational initiation | 1.65E-01 |
| negative regulation of cellular macromolecule biosynthetic process | 1.74E-01 |
| negative regulation of translational intitiation | 1.87E-01 |
| protein phosphorylation | 1.91E-01 |
| ruffle organization | 1.93E-01 |
| ruffle assembly | 2.14E-01 |
| negative regulation of translation | 2.48E-01 |
| negative regulation of macromolecule biosynthetic process | 2.62E-01 |
| negative regulation of cellular amide metabolic process | 2.71E-01 |
The top 3,000 ranked DE expressed liver transcripts as determined by microarray analysis from 5.8 nM DEHP and 0.65 nM EE2 exposed adult male zebrafish relative to control fish were used to search for enriched GO: Biological Process terms. The most significant terms for the DEHP and EE2 exposures, and those unique to DEHP (i.e. not present in in EE2 exposed) are presented.