Table 2.
GO: Biological Process and Co-expression analysis.
| GO Term | Bonferroni q-value |
|---|---|
| GO: Biological Process | |
| DEHP - Total | |
| organonitrogen compound biosynthetic process | 3.87E-16 |
| response to steroid hormone | 3.91E-11 |
| cell cycle process | 5.23E-11 |
| programmed cell death | 2.76E-10 |
| EE2 - Total | |
| response to endogenous stimulus | 7.10E-16 |
| oxoacid metabolic process | 1.03E-14 |
| peptide metabolic process | 8.23E-12 |
| apoptotic process | 1.38E-11 |
| DEHP - Unique | |
| cell cycle | 2.00E-05 |
| RNA processing | 1.80E-04 |
| positive regulation of transcription, DNA-templated | 7.85E-04 |
| ribonucleoprotein complex biogenesis | 1.19E-03 |
| EE2 - Unique | |
| negative regulation of transcription from RNA polymerase II promoter | 2.56E-04 |
| regulation of cell differentiation | 1.94E-03 |
| negative regulation of gene expression | 1.22E-02 |
| negative regulation of cellular biosynthetic process | 1.09E-01 |
| Co-Expression | |
| DEHP - Total | |
| Genes whose promoters are bound by MYC [GeneID = 4609], according to MYC | |
| Target Gene Database. | 1.85E-24 |
| Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples | |
| compared to those in the robust Cluster 1 (rC1). | 2.26E-24 |
| Genes up-regulated through activation of mTORC1 complex. | 3E-22 |
| EE2 - Total | |
| Human Liver_Tzur09_1908genes | 7.19E-22 |
| Human orthologs of genes up-regulated in the crb (‘crash and burn’) zebrafish | |
| mutant that represents a loss-of-function mutation in BMYB [GeneID = 4605]. | 6.07E-21 |
| DEHP - Unique | |
| Genes down-regulated in erythroid progenitor cells from fetal livers of E13.5 | |
| embryos with KLF1 [GeneID = 10661] knockout compared to those from the wild type embryos. | 4.59E-14 |
| Genes up-regulated through activation of mTORC1 complex. | 8.83E-06 |
| EE2 - Unique | |
| Mouse Liver_White05_638genes | 3.21E-06 |
| Rat Liver_Perez-Carreon06_290genes | 4.21E-04 |
The top 3,000 ranked DE expressed liver transcripts as determined by microarray analysis from 5.8 nM DEHP and 0.65 nM EE2 exposed adult male zebrafish relative to control fish were mapped to their human homologs using Ensembl homology. GO: Biological Process and co-expression terms and were enriched using ToppFun. The most significant terms for the DEHP and EE2 exposures, and those unique to DEHP (i.e. not present in in EE2 exposed) are presented.