Table 4.
RNA-Seq: GOrilla functional enrichment analysis.
| GO Term | Bonferroni q-value |
|---|---|
| DEHP Total | |
| translation | 6.09E-14 |
| lipid metabolic process | 1.05E-08 |
| lipid biosynthetic process | 7.01E-08 |
| response to estrogen | 2.94E-04 |
| cytoplasmic translation | 5.19E-04 |
| response to hypoxia | 1.24E-02 |
| EE2 - Total | |
| lipid biosynthetic process | 8.58E-07 |
| lipid metabolic process | 2.58E-04 |
| triglyceride metabolic process | 2.05E-02 |
| triglyceride-rich lipoprotein particle remodeling | 6.13E-02 |
| triglyceride catabolic process | 9.03E-02 |
| regulation of insulin-like growth factor receptor signaling pathway | 1.03E-01 |
| DEHP - Unique | |
| translation | 3.10E-16 |
| fatty acid biosynthetic process | 1.26E-15 |
| protein metabolic process | 1.29E-02 |
Significant DE expressed liver transcripts (FDR < 0.4) as determined by RNA-Seq from 5.8 nM DEHP and 0.65 nM EE2 exposed adult male zebrafish relative to control fish. The most significant terms for the DEHP and EE2 exposures, and those unique to DEHP (i.e. not present in in EE2 exposed) are presented.