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. 2016 Oct 18;23(2):335–343. doi: 10.1038/mp.2016.167

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Meta-analysis of antidepressant activity of anti-cytokine treatment. (a) Meta-analysis of RCTs of anti-cytokine drug vs. placebo. (b) Meta-analysis of RCTs of anti-cytokine drug plus DMARD vs. DMARD. (c) Meta-analysis of other trials (non-randomised and/or non-placebo). CI, confidence interval; DMARD, Disease Modifying Anti-rheumatoid Drug; RCT, randomised controlled trial.