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. 2018 Feb 1;8:2044. doi: 10.1038/s41598-018-20481-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of mBMSC and EA treatment on the expression of mBDNF and NT4 in neurons. (A) Photomicrographs and (B,C) histograms for mBDNF/NeuN or NT4/NeuN double-positive cells in the striatum and hippocampus (n = 5). The number of mBDNF/NeuN double-positive cells in the SVZ + striatum and hippocampus was significantly higher in the EA-treated MCAO group and the combined mBMSC + EA-treated MCAO group, compared to the number in the other groups. The number of NT4/NeuN double-positive cells in the hippocampus was significantly higher in the EA-treated MCAO group than in the vehicle-treated MCAO group. ^#p < 0.05 and ^##p < 0.01 versus control group; ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001 versus vehicle-treated MCAO group; ^&&p < 0.01 versus mBMSC-treated MCAO group. Scale bar = 100 μm.