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. 2018 Feb 1;8:2044. doi: 10.1038/s41598-018-20481-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of mBMSC and EA treatment on the expression of pCREB. (A,C) Photomicrographs and (B,D) histograms for pCREB and pCREB/Dcx (n = 5). pCREB expression in the striatum was markedly increased by treatment with mBMSC or EA. The number of pCREB/Dcx double-positive cells was significantly higher in the combination treatment MCAO group than in the control group. pCREB/Dcx double-positive cells are indicated by arrows. ^#p < 0.05 versus control group; ^*p < 0.05 and ^**p < 0.01 versus vehicle-treated group. Scale bars = 1 mm (A) and 100 μm (C).