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. 2018 Feb 1;8:2185. doi: 10.1038/s41598-018-20582-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antioxidants reduce PVL-stimulated release of neutrophil secretion products and NETosis. Supernatants from human neutrophils stimulated ±PVL (25 nmol/L) or PMA (100 nM), in the absence and presence of either taurine (10 mmol/L) or resveratrol (50 µmol/L), for 1 h (a-d), or with vehicle controls NaCl (0.9%) and DMSO (0.05% in PBS) for taurine and resveratrol, respectively (e-h), were analysed by ELISA for: alpha-defensins HNP1–3 release (a, e), acrolein-bound protein formation (b, f), myeloperoxidase (MPO) release (c, g) or nucleosomes as a surrogate marker for NET formation (d, h). Data show mean ± SD from 3 independent experiments. Flow cytometric data represent means + SD of three independent experiments. Statistical significance was analyzed by one-way ANOVA followed by Dunnett’s multiple comparisons test (*p < 0.05, vs PVL or PMA without antioxidant).