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. 2018 Feb 1;8:2185. doi: 10.1038/s41598-018-20582-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simplified summary. PVL expressed by S. aureus induces neutrophil (PMNL) lysis and release of prothrombotic cytokines, defensins, myeloperoxidase, HOCl and HOCl-modified proteins, as well as NET formation. Subsequent platelet activation, microparticle release and aggregation ultimately drives thrombosis. High anti-PVL titre, defensin inhibition by serpins and staphylokinase and antioxidants glutathione and resveratrol are protective.