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. 2018 Feb 1;8:2083. doi: 10.1038/s41598-018-20374-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flowchart of patient selection in the present study. Among a total of 6,452 visually impaired participants, those with a history of depression prior to visual impairment (n = 161) and those who could not be matched with a sufficient number of control participants (n = 445) were excluded. Data from 5,846 visually impaired participants and 23,384 control participants were subsequently analyzed.