Table 2.
Structure of peptides tested in the heterologous receptor functional assay and summary of activity in eliciting a luminescent response.
Peptide Name | Peptide Sequence | EC50 (nM)a |
---|---|---|
AedaeACP | pQVTFSRDWNAa | 10.25 |
AedaeAKH | pQLTFTPSWa | NAb |
AedaeCRZ | pQTFQYSRGWNTNa | NAb |
AedaeCAPA1 | GPTVGLFAFPRVa | NAb |
AedaeCAPA-PK1 | AGNSGANSGMWFGPRLa | NAb |
aEC50 values are the averages of multiple independent biological replicates involving CHOK1-aeq cells transiently expressing AedaeACPR-I.
bNo activity (NA) detected when tested with peptide titres up to a maximum of 10 µM.