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. 2018 Feb 1;8:2050. doi: 10.1038/s41598-018-20450-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation of arrhythmia by high frequency pacing versus size of the fat infiltrates. The percentage of total in-excitable tissue is shown at which arrhythmia occurred and sustained for 1.68 s with a probability higher than 25% after 10 external stimuli with a period 240 ms (a). Detailed probability distribution for radius 50 μm and radius 400 μm (b). The peak of the distributions was found in Fig. 4a and was denoted by the same colour, green and red. Simulations were carried out in a tissue of area $76.8 \times 76.8 m m^{2}$ , where the radius of adipose infiltrates equals 400 μm.