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. 2018 Feb 1;8:2032. doi: 10.1038/s41598-018-20453-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Application of the mrcLBP to a mouse model of diabetic nephropathy reveals significant textural alterations. (a) Distribution of aggregated classifier scores after ten random cross-validations. Holdout images from STZ-treated mice (blue bars) show a strongly bimodal distribution of SVM scores, while holdouts from non-STZ-treated mice (orange bars) are unimodal, consistently receiving positive classifier scores. (b) Boxplot showing spread of the mean values of STZ and non-STZ scores from all cross-validations.