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. 2018 Feb 1;8:2161. doi: 10.1038/s41598-018-20520-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of increased EPOR signaling on macrophage markers in ocular tissue. (a) and (b) mRNA expression levels of macrophage markers (a) F4/80 and (b) CD206 in the RPE/choroids and retina of non-treated mWtEPOR and hMtEPOR mice (n ≥ 6 animals per treatment group). (c) Representative images of IBA-1/Pu.1 positive cells in choroidal tissue from mWtEPOR and hMtEPOR mice. (d) Comparison of the number of IBA-1/Pu.1 cells per image (n = 8–16 images per genotype). Results are means ± SEM. **p < 0.01, ***p < 0.001 relative to mWtEPOR non-treated control.