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. 2018 Feb 1;8:2161. doi: 10.1038/s41598-018-20520-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of increased EPOR signaling on LCNV lesions three days post laser treatment. (a) Representative images of CNV staining at three days post-laser. (b) Comparison of the number of IBA1/Pu.1 positive cells per CNV spot (n ≥ 12 spots per group). (c) Comparison of CNV volumes in mWtEPOR and hMtEPOR three days after laser treatment (n ≥ 12 spots per group). (d) Estimate of average macrophage cell volume within a CNV spot (n ≥ 12 spots per group) (e) and (f) mRNA expression levels of macrophage markers (e) F4/80 and (f) CD206 at three and seven days post-laser treatment (n = 5–8 animals per treatment group). Results are means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 relative to mWtEPOR non-treated control.