TABLE 2.

Relative EOPs of four phages on STA, its derived BIMs, and their CRISPR-Cas-silenced derivatives

Strain	EOP for phagea:
	7951	7952	7953	7954
STA WT	1	1	1	1
STA BIM1	(8.33 ± 0.12) × 10−8	0.55 ± 0.16	0.75 ± 0.28	0.84 ± 0.49
STA BIM1::pNZ44	(4.87 ± 0.61) × 10−6	4.95 ± 1.10	6.02 ± 0.68	6.33 ± 1.90
STA BIM1::pNZ44+Cas9-1i	1.03 ± 0.07	1.08 ± 0.27	0.93 ± 0.07	1.43 ± 0.30
STA BIM1::pNZ44+Cas9-1i (cured)	(2.21 ± 3.00) × 10−6	4.08 ± 3.50	4.04 ± 2.76	3.89 ± 3.41
STA BIM2	≤3 × 10−7	≤1 × 10−8	≤4 × 10−8	≤9 × 10−7
STA BIM2::pNZ44+Cas9-1i	≤3 × 10−7	≤4 × 10−7	(1.85 ± 2.62) × 10−7	≤4 × 10−7

^aValues preceded by a less-than-or-equal-to sign indicate the limit of detection of phage titer.