Table 2.
Positivity for CD4+ and CD8+ effector and memory phenotypes in healthy household contacts (HHC) and patients with pulmonary tuberculosis (PTB)
| Antigen | Phenotype | p‐value | AUC | CI 95% | Positivity in HHC (%) | Positivity in PTB (%) |
|---|---|---|---|---|---|---|
| ESAT‐6 | CD4+ CD45RA− CCR7+ | 0·0015 | 0·84 | 0·666–1·013 | 93·3 (14/15) | 20 (3/15) |
| Rv0753c | CD4+ CD45RA− CCR7+ | 0·0225 | 0·7444 | 0·568–0·920 | 73·3 (11/15) | 33·3 (5/15) |
| Rv0009 | CD4+ CD45RA− CCR7+ | 0·0443 | 0·7156 | 0·530–0·900 | 86·6 (13/15) | 46·6 (7/15) |
| ESAT‐6 | CD8+ CD45RA− CCR7+ | 0·0013 | 0·8444 | 0·689–0·999 | 93·3 (14/15) | 20 (3/15) |
| Rv2204c | CD8+ CD45RA− CCR7+ | 0·0107 | 0·7733 | 0·605–0·940 | 86·6 (13/15) | 40 (6/15) |
| Rv0753c | CD8+ CD45RA− CCR7+ | 0·0012 | 0·8467 | 0·707–0·986 | 80 (12/15) | 20 (3/15) |
| Rv0009 | CD8+ CD45RA− CCR7+ | 0·0024 | 0·8244 | 0·673–0·975 | 80 (12/15) | 20 (3/15) |
| Rv0753c | CD4+ CD45RA+ CCR7+ | 0·0294 | 0·7333 | 0·547–0·918 | 40 (6/15) | 80 (12/15) |
| ESAT‐6 | CD4+ CD45RA+ CCR7− | 0·050 | 0·7089 | 0·513–0·904 | 33·3 (5/15) | 80 (12/15) |
| Rv0753c | CD4+ CD45RA+ CCR7− | 0·0362 | 0·7244 | 0·535–0·913 | 33·3 (5/15) | 80 (12/15) |
| Rv0009 | CD4+ CD45RA+ CCR7− | 0·0591 | 0·7022 | 0·513–0·891 | 40 (6/15) | 80 (12/15) |
Central memory (Tcm) cell, CCR7+ CD45RA−; effector memory (Tem) cell,CCR7− CD45RA−; effector cell (CCR7− CD45RA+); and naive T cells, CCR7+ CD45RA+.