Table 3.
Positivity for various CD4+ and CD8+ T regulatory subtypes in healthy household contacts (HHC) and patients with pulmonary tuberculosis (PTB)
| Antigen | Phenotype | p‐value | AUC | CI 95% | Positivity in HHC (%) | Positivity in PTB (%) |
|---|---|---|---|---|---|---|
| ESAT‐6 | CD4+ FoxP3− CD25+ | 0·0362 | 0·7244 | 0·539–0·909 | 20 (3/15) | 66·6 (10/15) |
| Rv2204c | CD4+ FoxP3− CD25+ | 0·0202 | 0·7489 | 0·556–0·941 | 13·3 2/15) | 66·6 (10/15) |
| Rv0009 | CD4+ FoxP3− CD25+ | 0·0107 | 0·7733 | 0·604–0·942 | 33·3 5/15) | 80 (12/15) |
| ESAT‐6 | CD8+ FoxP3− CD25+ | 0·0051 | 0·8 | 0·628–0·971 | 0 (0/15) | 60 (9/15) |
| Rv2204c | CD4+ FoxP3+ CD25+ | 0·0066 | 0·7911 | 0·623–0·958 | 20 (3/15) | 73·3 (11/15) |
| Rv0009 | CD8+ FoxP3+ CD25− | 0·031 | 0·7089 | 0·512–0·904 | 26·6 4/15) | 73·3 (11/15) |
| Rv2204c | CD4+ FoxP3− CD25− | 0·0034 | 0·8133 | 0·659–0·967 | 73·3 11/15) | 20 (3/15) |
| Rv0753c | CD4+ FoxP3− CD25− | 0·0084 | 0·7822 | 0·613–0·951 | 60 (9/15) | 6·6 (1/15) |
| Rv0009 | CD4+ FoxP3− CD25− | 0·0114 | 0·7711 | 0·598–0·943 | 93·3 (14/15) | 40 (6/15) |
We considered CD3+ CD4+/CD8+ CD25+ FoxP3− as FoxP3− regulatory T (Treg) cells, CD3+ CD4+/CD8+ CD25+ FoxP3+ subset as Treg cells, CD3+ CD4+/CD8+ CD25− FoxP3+ subset as FoxP3+ Treg cells.