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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2017 Aug 30;13(1):53–63. doi: 10.1007/s11481-017-9764-3

Figure 8. Enhanced monoamine depletions are blocked by ketoprofen during EtOH drinking.

Figure 8

Meth alone resulted in significant depletions of dopamine in a) striatum, and 5-HT in b) striatum and c) prefrontal cortex (#p<0.05 vs. Water+Saline+Vehicle; 3-way ANOVA and post hoc Tukey tests; n=5–12/group). Previous exposure to EtOH significantly enhanced DA depletions in a) striatum, and 5-HT depletions in b) striatum and c) prefrontal cortex (&p<0.05 vs. Water+Meth+Vehicle). Treatment with Keto during EtOH drinking attenuated dopamine depletions in a) striatum, and 5-HT depletions in b) striatum and c) prefrontal cortex (*p<0.05 vs. EtOH+Meth+Vehicle).