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. 2018 Jan 10;16:2. doi: 10.1186/s12915-017-0470-7

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© Youle et al. 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5. — High molecular weight (HMW) complex formation of PINK1. PINK1 forms a high molecular weight (HMW) complex with the TOM complex on the OMM in response to ΔΨm loss. Tom7, an accessory subunit of the TOM complex, may be involved in the lateral release of PINK1 into the OMM. The TOM complex is considered to provide a location for the activation of PINK1 kinase activity by facilitating the correct orientation of dimeric PINK1 to allow auto-phosphorylation in trans. At the same time, HMW complex formation with the TOM complex may allow rapid PINK1 re-import when mitochondria are repolarized to halt mitophagy