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. 2018 Jan 5;16:2. doi: 10.1186/s12964-018-0215-4

Fig. 7.

Fig. 7

In vivo chemotherapeutic responsiveness of MDA-hyb1 cells. In vivo chemotherapeutic response to 25 mg/kg taxol was tested after subcutaneous injection of 2 × 106 MDA-MB-231GFP cells or 2 × 106 MDA-hyb1cherry cells into 6 NODscid mice, respectively (3 mice for control and 3 mice for taxol-treatment). Based on an average weight of 20 g/mouse gavage was performed with 0.5 mg/200 μL taxol twice weekly and 200 μL solvent in control mice starting 4d after tumor cell application. The twelve mice were euthanized after 22d (MDA-Hyb1cherry) and 26d (MDA-MB-231GFP) and dissected tumors were quantified for tumor size and analyzed for distant organ metastases by fluorescence microscopy (n.d. = not detectable)