Table 2.
Univariate and multivariate Cox’s proportional hazard regression analyses of Pakistani breast cancer cohort for potential predictors of overall survival
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| SHH | 3.14 (1.3–7.7) | 0.01 | ||
| Age | 0.18 (0.06–0.45) | 0.0003 | 0.2 (0.08–0.56) | 0.002 |
| SHH | 3.89 (1.6–9.2) | 0.002 | ||
| ER | 2.67 (1.2–6.0) | 0.02 | 2.26 (0.97–5.25) | 0.05 |
| SHH | 3.53 (1.5–8.4) | 0.004 | ||
| PR | 1.76 (0.9–3.5) | 0.09 | – | – |
| SHH | 3.58 (1.5–8.6) | 0.004 | ||
| HER-2 | 1.16 (0.6–2.1) | 0.6 | – | – |
| SHH | 3.93 (1.7–9.3) | 0.002 | ||
| Metastasis | 2.96 (1.1–8.3) | 0.03 | 2.62 (1.3–5.3) | 0.007 |
| SHH | 3.79 (1.6–9.0) | 0.002 | ||
| DHH | 2.83 (1.2–6.8) | 0.02 | ||
| Age | 0.16 (0.07–0.43) | 0.0002 | 0.17 (0.1–0.5) | 0.0003 |
| DHH | 2.94 (1.2–6.9) | 0.01 | ||
| ER | 2.78 (1.2–6.3) | 0.01 | 2.00 (0.8–4.9) | 0.13 |
| DHH | 2.42 (1.0–5.8) | 0.04 | ||
| PR | 1.97 (1.0–3.85) | 0.05 | 2.04 (0.97–4.3) | 0.06 |
| DHH | 2.56 (1.1–6.1) | 0.03 | ||
| HER-2 | 1.16 (0.6–2.1) | 0.62 | – | – |
| DHH | 2.72 (1.2–6.5) | 0.02 | ||
| Metastasis | 3.97 (1.9–7.9) | 0.0001 | 2.9(1.4–5.9) | 0.003 |
| DHH | 3.16 (1.3–7.5) | 0.009 | ||
| GLI1 | 3.67 (1.7–7.9) | 0.0008 | ||
| Age | 0.17 (0.07–0.43) | 0.0002 | 0.18 (0.1–0.5) | 0.0004 |
| GLI1 | 4.67 (2.2–9.8) | <0.0001 | ||
| ER | 2.43 (1.1–5.5) | 0.03 | 2.45 (1.1–5.6) | 0.03 |
| GLI1 | 3.98 (1.9–8.4) | 0.0003 | ||
| PR | 1.26 (0.6–2.6) | 0.52 | – | – |
| GLI1 | 4.15 (1.9–9.1) | 0.0004 | ||
| HER-2 | 1.01 (0.5–1.9) | 0.98 | – | – |
| GLI1 | 4.51 (2.2–9.5) | <0.0001 | ||
| Metastasis | 2.54 (1.3–5.1) | 0.009 | 1.85 (1.9–3.8) | 0.009 |
| GLI1 | 4.01 (1.9–8.5) | 0.0003 | ||
Bold values show significance at p < 0.05, covariates significant in univariate analyses were considered for multivariate analyses