Table 3.
Functional Connectivity Analysis. MNI coordinates showing increased functional connectivity with right ventral striatum for music>scrambled across all sessions (main effect, top panel). Functional connectivity between right ventral striatum and auditory cortex increased on cannabis with CBD compared with cannabis without CBD (drug effect, bottom panel); +Additional peak within cluster. All P values are thresholded at P<.05 (False Discovery Rate-corrected for multiple comparisons)
| X | y | z | mm3 | Z | P | |
|---|---|---|---|---|---|---|
| Main effect | ||||||
| R Planum temporale | 60 | -12 | 6 | 5319 | 6.43 | <.001 |
| R Heschls gyrus/planum polare | 48 | -12 | 0 | + | 6.42 | <.001 |
| R Planum temporale | 48 | -27 | 9 | + | 6.26 | <.001 |
| L Heschls gyrus | -42 | -24 | 12 | 3429 | 6.31 | <.001 |
| L Planum temporale | -42 | -30 | 6 | + | 6.27 | <.001 |
| L Planum temporale | -33 | -33 | 15 | + | 5.48 | <.001 |
| R Caudate | 9 | 15 | 9 | 54 | 2.42 | .037 |
| Drug effect (cannabis with CBD>cannabis without CBD) | ||||||
| R Heschls gyrus | 42 | -18 | 9 | 1620 | 4.63 | .003 |
| L Hippocampus | -30 | -18 | -21 | 81 | 3.64 | .009 |
| L Heschls gyrus | -36 | -27 | 9 | 54 | 3.08 | .030 |
| L Heschls gyrus | -45 | -24 | 15 | 27 | 3.05 | .031 |