Table 2.
Summary of acetylcholinesterase inhibition based biosensors.
| Transducer | Inhibitor (Drug) | Detection Method | Detection Limit | Sample | References |
|---|---|---|---|---|---|
| GCE/AuNPs-Si-SG/AchE | Galantamine | Cyclic voltammetry and amperometry | - | - | [16] |
| Neostigmine | |||||
| Pt/AchE | Tacrine | Chronoamperometry | - | - | [18] |
| 7-Methoxy-Tacrine (7-MEOTA) | |||||
| Flow-through sensor/AchE | Neostigmine | Amperometric flow injection | - | - | [70] |
| SPE/TTF/AchE | Codeine | Chronoamperometry | - | Urine and pharmaceutical tablets | [71] |
| TTF-TCNQ-IL/AchE | Neostigmine | Chronoamperometry | 0.3 nM (Neostigmine) | Tap water | [72] |
| Eserine | 26 pM (Eserine) | ||||
| GE/BODT-co-FMOC/Cho/AchE | Neostigmine | Amperometry | 2.5 nM (Neostigmine) | Tap water | [73] |
| Donepezil | 0.071 nM (Donepezil) | ||||
| Flow-through sensor/AchE | Neostigmine | Amperometric flow injection | - | - | [69] |
| Eserine | |||||
| Tacrine | |||||
| Donepezil | |||||
| Rivastigmine | |||||
| Pyridostigmine | |||||
| Galantamine | |||||
| SPE/MPs/AchE | Galantamine | Square wave voltammetry | 1.5 µM | - | [74] |
AuNPs: Gold nanoparticles; Si-SG: Silica sol-gel; TTF: Tetrathiafulvalene; TCNQ-IL: Tetracyanoquinodimethane ionic liquid gel; BODT-co-FMOC: 5,6-bis(octyloxy)-4,7-di(thiophen-2-yl)benzo[c][1,2,5]oxadiazole(BODT) with (2-(((9H-fluoren-9-yl)methoxy)carbonylamino) acetic acid (FMOC); SPE: Screen-printed electrode; MPs: Magnetic particles; AchE: Acetylcholinesterase.