. 2018 Jan 9;18(1):164. doi: 10.3390/s18010164

Table 5.

Summary of different CYP isoforms and corresponding biosensors used for inhibition studies.

Transducer	Detection Method	Inhibitor (Drug)	$I_{50}$ / $K_{i}$	Reference
Au-NT/CPR/CYP3A4	CV	Ketoconazole	-	[100]
CNF/CYP3A4	CV	Ketoconazole	$I_{50}$ = 58.5 mM	[101]
MWCNT/CYP1A2	CV	Naproxen	-	[102]
		Linear range: 50–300 µM
		(LOD = 16 µM)
MWCNT/CYP3A4	CV	Dextromethorphan	-	[103]
MWCNT/CYP3A4	CV	Abiraterone (irreversible)	-	[20]
MWCNT/CYP3A4	CV	linear range:1–3 µM	-	[20]
MWCNT/CYP3A4	CV	Abiraterone	-	[104]
		(LOD = 230 nM)
		Dynamic range up to 1 µM
Au-PANSA/CYP2D6	DPV	Paroxetine (reversible)	$K_{i} = 0.02$ µM	[105]
	CA	linear range: 0.005–0.05 µM	$I_{50}$ = 0.03 µM
	SWV	(LOD = 2 nM)	$I_{50}$ = 0.03 µM
Au-NPs-PANAM dendrimers/CYP3A4	CV	Erythromycin	-	[106]
PG/DNA/CYP101	SWV	Sulconazole	$K_{i} = 204.2$ μM	[17]

NT: naphtalenethiolates; Au: gold electrode; CPR: Cytochrome reductase; CNF: Carbon nanofibers; MWCNTs: multiwalled carbon nanotubes; PANSA: Poly(8-anilino-1-napthalene sulphonic acid); PAMAM: Polyamido-amine; PG: Pyrolitic graphite; CV: Cyclic voltammetry; SWV: Square Wave Voltammetry; DPV: differential pulse voltammetry; CA: chronoamperometry.