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. 2017 Dec 30;10(1):13. doi: 10.3390/v10010013

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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THP-1-CD4^R cells express CD4 independently of miR-221 and miR-222 modulation. **** p < 0.0001. (A) Either undifferentiated or PMA-differentiated THP-1-CD4^R cells (or the control THP-1^ve cells, WT) were analyzed for their viability and the surface levels of CD4, CXCR4 or CCR5 by cytofluorometry. Representative graphs are shown. Mean geometric fluorescence intensities (MFIs) or viability values are shown in the histograms. (B) The expression of miR-221 or miR-222 was compared in THP-1-CD4^R cells prior or after differentiation (n = 12; means ± SD are shown and compared using Student’s t test). (C) Expression of CD4 was measured by western blot in either control THP-1^ve or THP-1-CD4^R cells, prior or following PMA-induced differentiation. A representative blot is shown.