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. 2017 Dec 30;10(1):13. doi: 10.3390/v10010013

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

MiR-221/miR-222 antagomirs restore CD4 expression in differentiated THP-1 cells to that of levels in undifferentiated THP-1 cells. ** p < 0.01 and **** p < 0.0001. (A) Control THP-1 or THP-1-CD4^R cells were PMA-differentiated and transfected with a mix of miR-221/miR-222 antagomirs. CD4 mRNA levels were then measured by qRT-PCR (n = 6; means ± SD are shown and compared using Student’s t test). (B) The levels of surface CD4 of the previously described cells were assessed by cytofluorometry; a graph of a representative experiment is shown (left panel; geometric MFIs are shown in parentheses) and a bar graph of the relative geometric MFIs (n = 2; means ± SD are shown and compared using Student’s t test) is provided in the right panel.