Figure 1.

(A) Definition of the three classes (C1, C2 and C3) used in this study to segregate subjects into “progressors” and “non-progressors” or in relation to their ability to control viral replication. These classes were used to construct decision trees. (B) The whole database was subdivided into three self-including parts, i.e., the small database (N = 27), the intermediate base (N = 48) and the entire base (N = 75). The dataset used in each analysis is indicated in the text. CD4⁺ and CD8⁺ T-cell counts and viral load (VL) were determined in all subjects. Additionally, Human Leukocyte Antigen (HLA) and C-C chemokine receptor type 5 (CCR5) genotyping (and the corresponding genetic scores (GS, Appendix A)), HIV-specific immune responses and immune activation were determined in a subset of 48 subjects. Finally, 40 plasma soluble factors (39 cytokines and chemokines plus lipopolysaccharide (LPS) were quantified in a smaller group (N = 27). The values obtained for each soluble factor were used individually but also additive scores were constructed (CS, cytokine scores, Appendix A variables plasma soluble factor (PSF)41 to PSF52). IA: Immune activation; IR: Immune response.