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Disassembly of the nuclear lamina during nuclear egress of HCMV capsids visualized by electron microscopy. HFFs were infected with HCMV strain AD169 (b) or remained uninfected (mock; (a)) as indicated. Cells were harvested at 3 dpi and subjected to immunogold staining of A-type lamins (i.e. lamin A/C). Samples were analysed by TEM, 35,970-fold magnification. NE, nuclear envelope; open arrowheads, intranuclear HCMV capsids; filled arrowheads, HCMV capsids budding at nuclear membranes.
