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. 2018 Jan 15;10(1):37. doi: 10.3390/v10010037

Figure 2.

Figure 2

Architecture of mammalian human papillomavirus (HPV) E6. (A) Secondary structure elements of mammalian HPV16 E6. E6N is shaded in blue, E6C is shaded in gray; (B) Superimposition of HPV16 E6N domain solved by NMR [91] and HPV16 E6N domain from the crystal structure of the E6/E6AP LxxLL complex [75]; (C) Superimposition of HPV16 E6C domain from the crystal structure of the E6/E6AP LxxLL complex [75], HPV51 E6C domain solved by NMR [101] and bovine papillomavirus 1 (BPV1) E6C domain from the crystal structure of the BPV1 E6/paxillin LxxLL complex [75]; (D) Superimposition of HPV16 E6N and E6C domains from the crystal structure of the HPV16 E6/E6AP LxxLL complex [75]; (E) Structure of LxxLL-bound mammalian HPV16 E6 [75] (LxxLL motif not shown for clarity). Zinc-coordinating cysteines are highlighted in red. Secondary elements are numbered as in [75]. Spheres are Zinc (II) atoms. All structural views in this article were prepared using Pymol (http://www.pymol.org/).