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. 2017 Oct 17;11(1):1–10. doi: 10.1007/s12195-017-0511-x

Figure 2.

Figure 2

Knockdown of Girdin results in morphological differences. (a) Time-lapse phase contrast images of a single control and Girdin siRNA-treated cell in a microtrack over a period of 120 min, yellow arrows and dashed outlines indicate the direction of migration and initial positions of cells at the beginning of migration, respectively; (b) Plotted aspect ratio of the same single control and Girdin siRNA-treated cells (showed in 3C) migrating through microtracks in a total time period of 120 at 20 min intervals; c Average aspect ratio and (d) Average circularity of control and Girdin knockdown MDA-MB-231 cells in microtracks. Scale bars 25 µm, # of cells per treatment = 35, **p value < 0.01.