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. Author manuscript; available in PMC: 2018 Feb 2.
Published in final edited form as: J Med Chem. 2017 Aug 14;60(16):7186–7198. doi: 10.1021/acs.jmedchem.7b00966

Figure 4.

Figure 4

In vivo pharmacokinetics of DON following iv administration of DON (14) and 13d in swine plasma and brain. DON (14, 1.6 mg/kg, iv) or an equivalent dose of 13d was administered to swine. Swine were sacrificed, and plasma and brain (60 min) concentrations of 14 were evaluated via LC-MS/MS. Relative to 14, compound 13d delivered (A) lower 14 plasma concentrations and (B) comparable 14 brain concentrations, resulting in (C) a 9-fold enhanced brain:plasma ratio at 60 min postadministration. Data are depicted as mean ± SEM (n = 2/group). Free levels of 14 in the swine brain (Fb = 91%) were calculated to be 0.46 and 0.53 nmol/g following 14 and 13d administration, respectively.