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. Author manuscript; available in PMC: 2018 Feb 2.
Published in final edited form as: J Med Chem. 2017 Aug 14;60(16):7186–7198. doi: 10.1021/acs.jmedchem.7b00966

Scheme 2. Synthesis of 4-Nitrophenyl Esters of Pivaloyloxy-alkoxycarbonate Intermediate 8a.

Scheme 2

aReagents and conditions: (a) triphosgene, pyridine, Et2O, –20 °C to rt, 20 h; (b) 4-nitrophenol, pyridine, DCM, 0 °C to rt, 2 h; (c) Hg(OPiv)2, DCM, rt, 16 h.