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. Author manuscript; available in PMC: 2018 Feb 2.
Published in final edited form as: J Med Chem. 2017 Aug 14;60(16):7186–7198. doi: 10.1021/acs.jmedchem.7b00966

Table 2.

Total and Free DON (14) Concentrations 60 min Post-Administration of 14 or 13d in Swine (1.6 mg/kg Equivalent, iv)

brain (nmol/g)
plasma (nmol/mL)
CSF (nmol/mL)
total free total free total
14 5.15 ± 1.40 0.464 ± 0.126 41.2 ± 12.2 32.5 ± 9.64 0.252
13d 5.90 ± 0.590 0.531 ± 0.053 4.88 ± 1.50 3.86 ± 1.19 1.10