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. Author manuscript; available in PMC: 2018 Feb 2.
Published in final edited form as: J Med Chem. 2017 Aug 14;60(16):7186–7198. doi: 10.1021/acs.jmedchem.7b00966

Table 3.

Total and Free DON (14) Ratios 60 min Post-Administration of 14 or 13d in Swine (1.6 mg/kg Equivalent, iv)

brain:plasma
CSF:plasma
CSF:brain
total:total free:free total:total total:free total:free
14 0.148 ± 0.078 0.017 ± 0.001 0.005 0.006 0.543
13d 1.38 ± 0.544 0.157 ± 0.062 0.069 0.087 2.07