Table II.
Univariate and multivariate Cox regression analyses of overall survival in 70 patients with renal cell carcinoma.
| Tumor characteristics | HR (95% CI) | P-value |
|---|---|---|
| Univariate analysis | ||
| Age (≥60 vs. <60) years | 1.461 (0.943–2.265) | 0.090 |
| Sex (male vs. female) | 0.978 (0.575–1.664) | 0.935 |
| Histological grade (poor/well) | 1.784 (1.130–2.818) | 0.013a |
| Tumor size (>5 vs. ≤5) cm | 1.454 (0.950–2.227) | 0.085 |
| Tumor stage (III, IV/I, II) | 2.512 (2.112–2.987) | <0.001a |
| Lymph node metastasis (positive vs. negative) | 2.336 (1.966–2.776) | <0.001a |
| Distant metastasis (positive vs. negative) | 2.621 (1.984–3.462) | <0.001a |
| Fbxw7 (high vs. low) | 0.465 (0.360–0.601) | <0.001a |
| Multivariate analysis | ||
| Histological grade (poor/well) | 1.436 (0.906–2.275) | 0.124 |
| Tumor stage (III, IV/I, II) | 1.962 (1.626–2.369) | <0.001a |
| Lymph node metastasis (positive vs. negative) | 1.784 (1.459–2.181) | <0.001a |
| Distant metastasis (positive vs. negative) | 1.621 (1.225–2.145) | <0.001a |
| Fbxw7 (high vs. low) | 0.623 (0.479–0.810) | <0.001a |
a
P<0.05. HRs, hazard ratios; CI, confidence interval.