Immunohistochemical analysis of protein expression. Expression of phosphorylated (p)-c-Met, p-AKT, and p-ERK was high in the dimethyl sulfoxide (DMSO) control group but low in mice treated with PHA-665752 plus vemurafenib. Images are representative of immunostained tumor samples taken from the control and drug-treated groups. H&E, scale bar, 100 µm; IHC, scale bar, 50 µm. ERK, extracellular signal-regulated kinase; c-Met, MET proto-oncogene, receptor tyrosine kinase.