Table II.
Association between various pathological factors and MMP-7 expression.
| MMP-7 expression at the invasive front | ||||
|---|---|---|---|---|
| Pathological factors | Positive (n=104) | Negative (n=85) | OR (95% CI) | P-valuea |
| Tumor budding | 1.20 (0.45–3.38) | 0.821 | ||
| + | 13 | 9 | ||
| − | 91 | 76 | ||
| Lymphatic invasion | 1.16 (0.56–2.43) | 0.733 | ||
| + | 26 | 19 | ||
| − | 78 | 66 | ||
| Venous invasion | 2.67 (1.29–5.74) | 0.005 | ||
| + | 38 | 15 | ||
| − | 66 | 70 | ||
| Por/Muc component | 0.85 (0.36–1.99) | 0.697 | ||
| + | 16 | 15 | ||
| − | 88 | 70 | ||
| Growth type | 1.24 (0.65–2.37) | 0.540 | ||
| PG | 70 | 53 | ||
| NPG | 34 | 32 | ||
| Morphology | 1.48 (0.66–3.45) | 0.350 | ||
| Depressed type | 22 | 13 | ||
| Non-depressed type | 82 | 72 | ||
| DR on the superficial layer | 1.18 (0.53–2.66) | 0.712 | ||
| + | 21 | 15 | ||
| − | 83 | 70 | ||
| Depth of invasion, µm | 1.00 (0.49–2.01) | 1.000 | ||
| <1,000 | 27 | 22 | ||
| ≥1,000 | 77 | 63 | ||
| Kudo's classification of degree of submucosal invasion | 1.13 (0.52–2.45) | 0.856 | ||
| sm1a, 1b | 20 | 18 | ||
| sm1c, 2, 3 | 84 | 67 | ||
| MM grade | 1.52 (0.59–4.00) | 0.383 | ||
| 2 | 93 | 72 | ||
| 1 | 11 | 13 | ||
a
Statistical analyses were performed using the Fisher's exact tests. CI, confidence interval; DR, desmoplastic reaction; MM muscularis mucosae; MMP-7, matrix metalloproteinase-7; Muc, mucinous carcinoma; NPG, non-polypoid growth; OR, odds ratio; PG, polypoid growth; Por, poorly differentiated adenocarcinoma.