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Effects of Endostar on the mRNA levels of (A) HIF-1α and (B) VEGF in liver tissue of hepatoma 22-bearing C57BL/6 mice. All experiments were performed at least three times. Results are presented as the mean ± standard deviation (n=6). #P<0.05, ##P<0.01, model vs. blank control. *P<0.05, **P<0.01, Endostar treatment vs. the model group at the same day. $$P<0.01, Endostar treatment vs. blank group. HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor.
