Table I.

Effect of Endostar on the levels of AFP, TNF-α and cAMP in hepatoma 22-bearing mice (n=6).

	AFP, ng/ml			TNF-α, pg/mg			cAMP, nmol/ml
Day	Blank	Model	Endostar	Blank	Model	Endostar	Blank	Model	Endostar
1	28.19±3.26	29.21±9.01	29.13±4.56	0.41±0.04	0.95±0.12	0.63±0.14	0.63±0.17	0.51±0.07	0.52±0.12
3		32.91±3.98a	30.17±6.11		3.51±0.91a	2.11±0.61c		0.45±0.08a	0.51±0.09
6		36.42±4.66a	31.62±5.87c		5.36±0.74b	2.45±0.85d		0.42±0.09b	0.49±0.12c
9		42.95±8.01b	35.21±4.03d		7.18±0.71b	3.27±0.97d		0.09±0.08b	0.39±0.09d
12		56.26±3.98b	49.82±4.65e		7.31±0.13b	7.08±1.01e		0.07±0.01b	0.16±0.03e

All experiments were performed at least three times.

^aP<0.05

^bP<0.01, model vs. blank control

^cP<0.05

^dP<0.01, Endostar treatment vs. the model group at the same day

^eP<0.01, the level at day 12 vs. the level at day 9 in the Endostar group. AFP, α-fetoprotein; TNF-α, tumor necrosis factor-α; cAMP, cyclic adenosine 5′-phosphate.