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. 2017 Dec 21;19(1):11. doi: 10.3390/ijms19010011

Figure 2.

Figure 2

One potentially common mechanism underlying antidepressant and analgesic effects of LAC. LAC enhances mGlu2 receptor (Grm2) gene transcription by acting as a donor of acetyl groups to NF-κB p65 and histones H3 and H4 [7,8,51,53,56].